The endocannabinoid system

Compatibility of CBD

Cannabis has a variety of different cannabinoids, but one of them is the cause of intoxication. The absolute majority of cannabinoids do not cause intoxication, but they have great medical potential. In particular, CBD is one such a cannabinoid with no psychoactive effect but a great medical potential, and since CBD is not psychoactive, it is legal and especially suitable for sensitive animals such as dogs and cats. Furthermore, the great medical potential of CBD is also due to its excellent safety profile, which is also confirmed by a report of the world health organisation (WHO). This means that CBD has no strong, dangerous or long-term side effects and can be considered safe and beneficial. However, concomitant use of CBD and other drugs or medicines should be discussed with your veterinarian first, due to the strong functionality of CBD.

What are cannabinoids?

The genus of hemp plants, designated in Latin Cannabis sativa L., are unique in nature, because only this species produces cannabinoids. In addition to these unique cannabinoids, the genus Cannabis sativa L. also produces a variety of other unique substances. A large part of these are so-called terpenes, the odorants of the plant. Together, the cannabinoids and terpenes form a group of hundreds of unique substances and some of them have already been shown to have great medical potential. It has also been observed that different substances work in combination with each other to potentiate their effects or neutralize unwanted side effects. For example, it has been demonstrated that CBD can reduce the psychoactive effect of THC. It has also been observed that cannabinoids can enhance their effects not only in combination with each other but also with terpenes and other compounds. This is commonly described as a “combination effect” or “entourage effect”. In order to make the best possible use of this valuable combination effect, we exclusively use natural hemp extracts with a full spectrum in our Paw-Treats products, which have been extracted with gentle methods. This ensures that no valuable substances are destroyed during production.

What is CBD and what can CBD do?

Cannabidiol or CBD is one of cannabinoids produced by the genus of cannabis plants. CBD is legal because it is not psychoactive and therefore not listed as an anaesthetic. This is one of the reasons why CBD is currently one of the best researched cannabinoids with a huge medical potential according to a large number of recent studies. Different studies suggest that CBD has many positive effects such as antioxidant, anti-inflammatory, anticonvulsant, antiemetic, anxiolytic and antipsychotic effects. Furthermore, CBD holds great potential in other areas, for example in the field of oncology. In addition to this the world health organisation WHO has rated CBD in its 2017 published report as substance with a very good safety profile and potentially high medicinal benefits.

How do cannabinoids work?

The effects and mechanisms of action of cannabinoids and even single cannabinoids such as CBD are highly diverse and complex. In general, however, it can be summarized that exogenous cannabinoids (from plant sources) take over the function of endogenous messenger substances, so-called endogenous cannabinoids (such as anandamide). With the help of these messenger substances, many important body functions are regulated by the so-called endocannabinoid system (ECS). Every vertebrate organism possesses such an endocannabinoid system, and so also every human being and all animals. The endocannabinoid system comprises two different receptors, CB1 and CB2, which are found in different parts of the body and perform different functions. In particular, the ECS controls and regulates most important basic functions such as sleep, appetite, pain, immune system, inflammation, mood, body temperature, as well as memory and learning ability. The aim of the endocannabinoid system is to regulate or maintain an internal balance, which is essential for the stability and continuity of important physiological body functions in humans and animals. Accordingly, in situations of increased stress, by delivering exogenous cannabinoids (from plant sources), one can support the ECS to perform its functions. CBD thus can support the body maintain its natural balance and, in this way, reconcile body and mind.

CBD for phobias, stress and other anxieties

To date, more than 30 studies have been conducted on the effects of CBD on phobias, anxiety and stress. These studies have shown that CBD has an excellent effect in relieving anxiety and acute stress. It has also been shown that CBD also protects against the effects of ongoing stress. However, sometimes most importantly, these positive effects can be achieved even at low doses and without side effects.

CBD for pain, inflammation

In several studies, an anti-inflammatory and pain-relieving effect of CBD could be demonstrated. In particular, in painful inflammatory and chronic diseases such as osteoarthritis, a strong effect is observed, as the CBD reduces the formation of certain signaling substances, which leads to an increased pain sensation. In addition, in the regions in which pain sensations are processed, the brain has a higher number of CB1 and CB2 receptors by which pain sensations can be regulated.

CBD and cancer

Studies show that cannabinoids, e.g. CBD, also have great potential in oncology. Currently, CBD, but also other cannabinoids and cannabis extracts are used in this medical field to increase the well-being of patients. This by reducing pain, nausea and loss of appetite due to cancer or chemotherapy. In addition, various studies have shown that cancer cells react in very different ways to cannabinoids. On the one hand, cannabinoids can be used to mark cancer cells for their own immune system, causing them to be attacked and destroyed by the body. On the other hand, cannabinoids can prevent the cell division of cancer cells, stopping their spread and ultimately destroying the cancer cell. A third mechanism of action that has been observed is that cannabinoids in cancer cells can trigger a chain reaction that causes cancer cells to self-destruct. Thus, ECS also takes on its regulatory function, helping to identify and eliminate non-functioning cells, cancer cells.

CBD in relation to the aging process

The aging process is mainly driven by inflammatory and oxidative mechanisms. Free radicals also play an important role in this context. Due to the antioxidant and anti-inflammatory effect of CBD, it can counteract these central roles of the aging process and help to preserve the youthful health better.

CBD in behavioral disorders

Stress and anxiety can strongly influence the behavior of both humans and animals and lead to unwanted behavior, so-called behavioral disorders. Because CBD and other cannabinoids have anxiolytic and sedative properties, anxiety and stress-based behavioral disorders are deprived of the base, allowing the animal to return to its normal behavior.